Tang-Long Shen Professor Cell Biology Laboratory

◆ Plant Pathology (Viroid),
◆ Antrodia Cinnomomea,
◆ Cordyceps,
◆ Cancer Exosome,
◆ Metallothionein,
◆ FAK/Grb Signaling Transduction

Pei-Yu Chu
Postdoctoral Fellow

Emily Lo
Postdoctoral Fellow

沈秀如
Postdoctoral Fellow

荊士瑋
Research Assistant

林恩稚
M.S. Student

林柏鈞
M.S. Student

楊加宇
M.S. Student

王士誠
M.S. Student

郭尚哲
Ph.D. Student

1997 – 2002 PhD. in Cancer Cell Biology,
Department of Molecular Medicine,
Cornell University, USA

1992 – 1994 MS in Plant Virology,
Institute of Plant Pathology,
National Taiwan University, Taiwan

1987 – 1991 BS in Plant Pathology,
Department of Plant Pathology and Entomology,
National Taiwan University, Taiwan
◆ 細胞生物學特論
◆ 分子生物與細胞學 (Molecular and Cell Biology; 與日本京都大學合開 遠距教學)
◆ 科學方法與寫作 (合開)
◆ 書報討論 上 / 下
◆ 應用微生物 (合開)
◆ 生物分子交互作用之網絡 (Cellular Network of Biological Molecules 遠距教學)
◆ 植物病原交互作用分子機制 (合開)
◆ 分子生物學 (合開) Chp9, Chp10-11, Chp12
◆ 植物病毒學實驗 (合開)
◆ 幹細胞生長與分化技術 (合開)
◆ 生物技術核心實驗 (合開)
Year Article
2016

Characterization and application of a common epitope recognized by a broad-spectrum C4 monoclonal antibody against capsid proteins of plant potyviruses

Applied Microbiology and Biotechnology

vol.100,no.4,page.1853-1869

Liu, H.-L. and Liu, Y.-W. and Shen, T.-L. and Hsu, C.-H. and Chang, Y.-C.

2016

Activation of focal adhesion kinase through an interaction with β4 integrin contributes to tumorigenicity of colon cancer

FEBS Letters

Tai, Y.-L. and Lai, I.-R. and Peng, Y.-J. and Ding, S.-T. and Shen, T.-L.

2015

Tumour exosome integrins determine organotropic metastasis

Nature

vol.527,no.7578,page.329-335

Hoshino, A. and Costa-Silva, B. and Shen, T.-L. and Rodrigues, G. and Hashimoto, A. and Tesic Mark, M. and Molina, H. and Kohsaka, S. and Di Giannatale, A. and Ceder, S. and Singh, S. and Williams, C. and Soplop, N. and Uryu, K. and Pharmer, L. and King,

2015

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Nature Cell Biology

vol.17,no.6,page.816-826

Costa-Silva, B. and Aiello, N.M. and Ocean, A.J. and Singh, S. and Zhang, H. and Thakur, B.K. and Becker, A. and Hoshino, A. and Mark, M.T. and Molina, H. and Xiang, J. and Zhang, T. and Theilen, T.-M. and Garc{\'i

2015

Multiplex detection, distribution, and genetic diversity of Hop stunt viroid and citrus exocortis viroid infecting citrus in Taiwan

Virology Journal

vol.12,no.1

Lin, C.-Y. and Wu, M.-L. and Shen, T.-L. and Yeh, H.-H. and Hung, T.-H.

2015

Involvement of p38 MAPK in the anticancer activity of cultivated cordyceps militaris

American Journal of Chinese Medicine

vol.43,no.5,page.1043-1057

Chou, S.-M. and Lai, W.-J. and Hong, T. and Tsai, S.-H. and Chen, Y.-H. and Kao, C.-H. and Chu, R. and Shen, T.-L. and Li, T.-K.

2015

Evaluation of an Epitypified Ophiocordyceps formosana (Cordyceps s.l.) for Its Pharmacological Potential

Evidence-based Complementary and Alternative Medicine

vol.2015

Wang, Y.-W. and Hong, T.-W. and Tai, Y.-L. and Wang, Y.-J. and Tsai, S.-H. and Lien, P.T.K. and Chou, T.-H. and Lai, J.-Y. and Chu, R. and Ding, S.-T. and Irie, K. and Li, T.-K. and Tzean, S.-S. and Shen, T.-L.

2015

Establishment of a rapid PCR detection method for Antrodia salmonea and A. cinnamomea

Taiwan Journal of Forest Science

vol.30,no.1

Wu, M.-L. and Shen, T.-L. and Chang, T.-T. and Chen, C.-H. and Hung, T.-H. and Lee, C.-Y. and Lin, C.-Y.

2015

Emerging roles of focal adhesion kinase in cancer

BioMed Research International

vol.2015

Tai, Y.-L. and Chen, L.-C. and Shen, T.-L.

2015

An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer

Scientific Reports

vol.5

Tai, Y.-L. and Chu, P.-Y. and Lai, I.-R. and Wang, M.-Y. and Tseng, H.-Y. and Guan, J.-L. and Liou, J.-Y. and Shen, T.-L.

2015

A mutual titer-enhancing relationship and similar localization patterns between Citrus exocortis viroid and Hop stunt viroid co-infecting two citrus cultivars

Virology Journal

vol.12,no.1

Lin, C.-Y. and Wu, M.-L. and Shen, T.-L. and Hung, T.-H.

2014

Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells

Phytomedicine

vol.21,no.12,page.1516-1524

Chou, S.-M. and Lai, W.-J. and Hong, T.-W. and Lai, J.-Y. and Tsai, S.-H. and Chen, Y.-H. and Yu, S.-H. and Kao, C.-H. and Chu, R. and Ding, S.-T. and Li, T.-K. and Shen, T.-L.

2014

DNA topoisomerase III alpha regulates P53-mediated tumor suppression

Clinical Cancer Research

vol.20,no.6,page.1489-1501

Hsieh, M.-Y. and Fan, J.-R. and Chang, H.-W. and Chen, H.-C. and Shen, T.-L. and Teng, S.-C. and Yeh, Y.-H. and Li, T.-K.

2014

Cordycepin suppresses integrin/FAK signaling and epithelial-mesenchymal transition in hepatocellular Carcinoma

Anti-Cancer Agents in Medicinal Chemistry

vol.14,no.1,page.29-34

Yao, W.-L. and Ko, B.-S. and Liu, T.-A. and Liang, S.-M. and Liu, C.-C. and Lu, Y.-J. and Tzean, S.-S. and Shen, T.-L. and Liou, J.-Y.

2013

Topoisomerase II-mediated DNA cleavage and mutagenesis activated by nitric oxide underlie the inflammation-associated tumorigenesis

Antioxidants and Redox Signaling

vol.18,no.10,page.1129-1140

Yang, Y.-C. and Chou, H.-Y.E. and Shen, T.-L. and Chang, W.-J. and Tai, P.-H. and Li, T.-K.

2013

Cordycepin Regulates GSK-3β/β-Catenin Signaling in Human Leukemia Cells

PLoS ONE

vol.8,no.9

Ko, B.-S. and Lu, Y.-J. and Yao, W.-L. and Liu, T.-A. and Tzean, S.-S. and Shen, T.-L. and Liou, J.-Y.

2013

Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities

American Journal of Physiology - Lung Cellular and Molecular Physiology

vol.305,no.4

Schmidt, T.T. and Tauseef, M. and Yue, L. and Bonini, M.G. and Gothert, J. and Shen, T.-L. and Guan, J.-L. and Predescu, S. and Sadikot, R. and Mehta, D.

2012

Solution Structure of the Oncogenic MIEN1 Protein Reveals a Thioredoxin-Like Fold with a Redox-Active Motif

PLoS ONE

vol.7,no.12

Hsu, C.-H. and Shen, T.-L. and Chang, C.-F. and Chang, Y.-Y. and Huang, L.-Y.

2012

Multiple domains of the Tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencing

Molecular Plant-Microbe Interactions

vol.25,no.5,page.648-657

Wang, L.-Y. and Lin, S.-S. and Hung, T.-H. and Li, T.-K. and Lin, N.-C. and Shen, T.-L.

2012

Micropatterning of mammalian cells on inorganic-based nanosponges

Biomaterials

vol.33,no.20,page.4988-4997

Yang, C.-Y. and Liao, T.-C. and Shuai, H.-H. and Shen, T.-L. and Yeh, J.A. and Cheng, C.-M.

2012

Lysophosphatidic acid enhances vascular endothelial growth factor-C expression in human prostate cancer PC-3 cells

PLoS ONE

vol.7,no.7

Lin, C.-E. and Chen, S.-U. and Lin, C.-C. and Chang, C.-H. and Lin, Y.-C. and Tai, Y.-L. and Shen, T.-L. and Lee, H.

2012

14-3-3σ regulates β-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3β

PLoS ONE

vol.7,no.6

Chang, T.-C. and Liu, C.-C. and Hsing, E.-W. and Liang, S.-M. and Chi, Y.-H. and Sung, L.-Y. and Lin, S.-P. and Shen, T.-L. and Ko, B.-S. and Yen, B.L. and Yet, S.-F. and Wu, K.K. and Liou, J.-Y.

2011

The function of porcine PPARγ and dietary fish oil effect on the expression of lipid and glucose metabolism related genes

Journal of Nutritional Biochemistry

vol.22,no.2,page.179-186

Yu, Y.-H. and Wu, S.-C. and Cheng, W.T.K. and Mersmann, H.J. and Shen, T.-L. and Ding, S.-T.

2011

Serum amyloid a induces lipolysis by downregulating perilipin through ERK1/2 and PKA signaling pathways

Obesity

vol.19,no.12,page.2301-2309

Liu, L.R. and Lin, S.P. and Chen, C.C. and Chen, Y.J. and Tai, C.C. and Chang, S.C. and Juang, R.H. and Tseng, Y.W. and Liu, B.H. and Mersmann, H.J. and Shen, T.L. and Ding, S.T.

2011

Overexpression of 14-3-3ε predicts tumour metastasis and poor survival in hepatocellular carcinoma

Histopathology

vol.58,no.5,page.705-711

Ko, B.-S. and Chang, T.-C. and Hsu, C. and Chen, Y.-C. and Shen, T.-L. and Chen, S.-C. and Wang, J. and Wu, K.K. and Jan, Y.-J. and Liou, J.-Y.

2011

Interactions between cells and nanoscale surfaces of oxidized silicon substrates

World Academy of Science, Engineering and Technology

vol.76,page.195-201

Yang, C.-Y. and Huang, L.-Y. and Shen, T.-L. and Andrew Yeh, J.

2011

Increased expression of 14-3-3β promotes tumor progression and predicts extrahepatic metastasis and worse survival in hepatocellular carcinoma

American Journal of Pathology

vol.179,no.6,page.2698-2708

Liu, T.-A. and Jan, Y.-J. and Ko, B.-S. and Chen, S.-C. and Liang, S.-M. and Hung, Y.-L. and Hsu, C. and Shen, T.-L. and Lee, Y.-M. and Chen, P.-F. and Wang, J. and Shyue, S.-K. and Liou, J.-Y.

2010

Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses

European Journal of Pharmacology

vol.638,no.1-3,page.13-20

Fan, J.-R. and Huang, T.-H. and Wen, C.-Y. and Shen, T.-L. and Li, T.-K.

2010

Resonance assignments of human C35 (C17orf37) protein, a novel tumor biomarker

Biomolecular NMR Assignments

vol.4,no.2,page.191-193

Yang, C.-J. and Chang, C.-F. and Huang, L.-Y. and Chang, Y.-Y. and Shen, T.-L. and Hsu, C.-H.

2010

Preliminary crystallographic characterization of the Grb2 SH2 domain in complex with a FAK-derived phosphotyrosyl peptide

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

vol.66,no.2,page.195-197

Chen, H.-H. and Chen, C.-W. and Chang, Y.-Y. and Shen, T.-L. and Hsu, C.-H.

2010

Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance

American Journal of Pathology

vol.177,no.4,page.1629-1637

Lai, I.-R. and Chu, P.-Y. and Lin, H.-S. and Liou, J.-Y. and Jan, Y.-J. and Lee, J.-C. and Shen, T.-L.

2010

EGF-induced Grb7 recruits and promotes ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells

Journal of Biological Chemistry

vol.285,no.38,page.29279-29285

Chu, P.-Y. and Li, T.-K. and Ding, S.-T. and Lai, I.-R. and Shen, T.-L.

2010

Cell adhesion, morphology and biochemistry on nanotopographic oxidized silicon surfaces

European Cells and Materials

vol.20,page.415-430

Yang, C.-Y. and Huang, L.-Y. and Shen, T.-L. and Andrew Yeh, J.

2010

Bortezomib suppresses focal adhesion kinase expression via interrupting nuclear factor-kappa B

Life Sciences

vol.86,no.5-6,page.199-206

Ko, B.-S. and Chang, T.-C. and Chen, C.-H. and Liu, C.-C. and Kuo, C.-C. and Hsu, C. and Shen, Y.-C. and Shen, T.-L. and Golubovskaya, V.M. and Chang, C.-C. and Shyue, S.-K. and Liou, J.-Y.

2009

Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis

Journal of Biological Chemistry

vol.284,no.30,page.20215-20226

Chu, P.-Y. and Huang, L.-Y. and Hsu, C.-H. and Liang, C.-C. and Guan, J.-L. and Hung, T.-H. and Shen, T.-L.

2008

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

Journal of Cell Biology

vol.181,no.1,page.43-50

Weis, S.M. and Lim, S.-T. and Lutu-Fuga, K.M. and Barnes, L.A. and Chen, X.L. and G{\"o

2008

Ammonium hydroxide extracts from black tea inhibit growth, migration and invasion of colon cancer cells

Journal of Food Biochemistry

vol.32,no.2,page.201-215

Huang, H.-C. and Chen, H.-Y. and Chen, C.-Y. and Shen, T.-L. and Huang, J. and Lin, N.-Y. and Sum, S.-Y. and Che, M.-I. and Huang, M.-C.

2007

β1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells

Molecular Cancer Research

vol.5,no.6,page.543-552

Huang, J. and Liang, J.-T. and Huang, H.-C. and Shen, T.-L. and Chen, H.-Y. and Lin, N.-Y. and Che, M.-I. and Lin, W.-C. and Huang, M.-C.

2007

Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland

Journal of Biological Chemistry

vol.282,no.43,page.31766-31776

Nagy, T. and Wei, H. and Shen, T.-L. and Peng, X. and Liang, C.-C. and Gan, B. and Guan, J.-L.

2006

Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice

Journal of Clinical Investigation

vol.116,no.1,page.217-227

Peng, X. and Kraus, M.S. and Wei, H. and Shen, T.-L. and Pariaut, R. and Alcaraz, A. and Ji, G. and Cheng, L. and Yang, Q. and Kotlikoff, M.I. and Chen, J. and Chien, K. and Gu, H. and Guan, J.-L.

2006

C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells

Oncogene

vol.25,no.23,page.3267-3276

Huang, M.-C. and Chen, H.-Y. and Huang, H.-C. and Huang, J. and Liang, J.-T. and Shen, T.-L. and Lin, N.-Y. and Ho, C.-C. and Cho, I.-M. and Hsu, S.-M.

2005

Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase: Role of RHO family small GTPases

Journal of Biological Chemistry

vol.280,no.2,page.923-932

Miao, H. and Strebhardt, K. and Pasquale, E.B. and Shen, T.-L. and Guan, J.-L. and Wang, B.

2005

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

Journal of Cell Biology

vol.169,no.6,page.941-952

Shen, T.-L. and Park, A.Y.-J. and Alcaraz, A. and Peng, X. and Jang, I. and Koni, P. and Flavell, R.A. and Gu, H. and Guan, J.-L.

2004

Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice

Cardiovascular Research

vol.64,no.3,page.421-430

Peng, X. and Ueda, H. and Zhou, H. and Stokol, T. and Shen, T.-L. and Alcaraz, A. and Nagy, T. and Vassalli, J.-D. and Guan, J.-L.

2004

Grb7 in intracellular signaling and its role in cell regulation

Frontiers in Bioscience

vol.9,page.192-200

Shen, T.-L. and Guan, J.-L.

2004

Activation of FAK and Src are receptor-proximal events required for netrin signaling

Nature Neuroscience

vol.7,no.11,page.1213-1221

Li, W. and Lee, J. and Vikis, H.G. and Lee, S.-H. and Liu, G. and Aurandt, J. and Shen, T.-L. and Fearon, E.R. and Guan, J.-L. and Han, M. and Rao, Y. and Hong, K. and Guan, K.-L.

2003

Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction

Molecular and Cellular Biology

vol.23,no.22,page.8030-8041

Cooper, L.A. and Shen, T.-L. and Guan, J.-L.

2002

Nck-2 interacts with focal adhesion kinase and modulates cell motility

International Journal of Biochemistry and Cell Biology

vol.34,no.7,page.791-805

Goicoechea, S.M. and Tu, Y. and Hua, Y. and Chen, K. and Shen, T.-L. and Guan, J.-L. and Wu, C.

2002

EphB1 associates with Grb7 and regulates cell migration

Journal of Biological Chemistry

vol.277,no.47,page.45655-45661

Han, D.C. and Shen, T.-L. and Miao, H. and Wang, B. and Guan, J.-L.

2002

Association of Grb7 with phosphoinositides and its role in the regulation of cell migration.

Journal of Biological Chemistry

vol.277,no.32,page.29069-29077

Shen, T.L. and Han, D.C. and Guan, J.L.

2001

The Grb7 family proteins: Structure, interactions with other signaling molecules and potential cellular functions

Oncogene

vol.20,no.44 REV. ISS. 5,page.6315-6321

Dong Cho Han and Shen, T.-L. and Guan, J.-L.

2001

Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts

FEBS Letters

vol.499,no.1-2,page.176-181

Shen, T.-L. and Guan, J.-L.

2000

Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration

Journal of Biological Chemistry

vol.275,no.37,page.28911-28917

Han, D.C. and Shen, T.-L. and Guan, J.-L.